The gap between private loyalty and public responsibility
Joe believes that protecting his family is the highest moral duty. Miller shows that this logic breaks down when your private choices kill other people's sons. The play puts these two values in direct conflict and refuses to let Joe have both.
Denial as survival
Every member of the Keller family knows something they won't say out loud. Kate won't accept Larry's death. Joe won't admit his guilt. Chris won't push too hard because he wants his father to be good. The whole family structure depends on not knowing what they already know.
The American Dream's dark side
Joe built his business from nothing and sees it as proof that hard work pays off. But Miller shows that the dream of success can justify almost anything in a person's mind. Joe's crime is the price of his version of success, and he paid it with other people's lives.
The weight of the dead
Larry, the dead pilots, the war itself, all press down on the living characters. The dead don't appear, but they control everything. Larry's letter is the most direct example: a dead man's words end the play.
Father and son relationships
Joe wants Chris to inherit his business and his values. Chris wants to believe his father is a good man. When those two things turn out to be incompatible, the relationship breaks. Larry's response, choosing death over accepting his father's guilt, shows the most extreme version of that break.